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Yi-Hsien Hsieh Selected Research

norcantharidin

12/2022Norcantharidin attenuates epidermal growth factor-induced proliferation, EMT and motility in ARPE-19 cells by modulating the AKT/snail/E-cadherin axis.
11/2021Norcantharidin combined with paclitaxel induces endoplasmic reticulum stress mediated apoptotic effect in prostate cancer cells by targeting SIRT7 expression.
1/2018Induction of endoplasmic reticulum stress and mitochondrial dysfunction dependent apoptosis signaling pathway in human renal cancer cells by norcantharidin.
10/2017Norcantharidin induces mitochondrial-dependent apoptosis through Mcl-1 inhibition in human prostate cancer cells.
1/2017Correction: Antimetastatic Effects of Norcantharidin on Hepatocellular Carcinoma by Transcriptional Inhibition of MMP-9 through Modulation of NF-kB Activity.
1/2012Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity.

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Yi-Hsien Hsieh Research Topics

Disease

104Neoplasms (Cancer)
04/2024 - 02/2007
45Neoplasm Metastasis (Metastasis)
04/2024 - 05/2007
35Hepatocellular Carcinoma (Hepatoma)
12/2023 - 08/2006
20Uterine Cervical Neoplasms (Cancer of the Cervix)
12/2023 - 02/2012
15Osteosarcoma (Osteogenic Sarcoma)
04/2024 - 11/2016
12Mouth Neoplasms (Oral Cancer)
01/2024 - 09/2010
10Mitochondrial Diseases (Mitochondrial Disease)
11/2023 - 01/2017
9Fibrosis (Cirrhosis)
12/2023 - 12/2005
8Breast Neoplasms (Breast Cancer)
01/2023 - 09/2011
7Renal Cell Carcinoma (Grawitz Tumor)
10/2023 - 09/2015
7Glioma (Gliomas)
12/2022 - 04/2004
6Kidney Neoplasms (Kidney Cancer)
02/2023 - 01/2018
5Chronic Renal Insufficiency
12/2023 - 09/2020
5Prostatic Neoplasms (Prostate Cancer)
07/2023 - 09/2013
5Squamous Cell Carcinoma of Head and Neck
01/2022 - 05/2012
5Glioblastoma (Glioblastoma Multiforme)
10/2021 - 01/2015
5Inflammation (Inflammations)
09/2021 - 10/2011
5Carcinogenesis
01/2018 - 05/2007
5Lung Neoplasms (Lung Cancer)
01/2018 - 12/2014
4Ureteral Obstruction
01/2024 - 01/2021
3Liver Neoplasms (Liver Cancer)
10/2023 - 02/2008
3Carcinoma (Carcinomatosis)
05/2022 - 01/2017
3Hypoxia (Hypoxemia)
03/2021 - 05/2012
3Hypertension (High Blood Pressure)
01/2017 - 01/2005
3Pelvic Inflammatory Disease (Pelvic Inflammatory Diseases)
10/2011 - 06/2009
3Cardiomegaly (Heart Hypertrophy)
12/2005 - 01/2005
2Wounds and Injuries (Trauma)
04/2020 - 12/2017

Drug/Important Bio-Agent (IBA)

35Proteins (Proteins, Gene)FDA Link
01/2024 - 01/2005
12Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
12/2023 - 12/2010
10Matrix Metalloproteinases (MMPs)IBA
06/2023 - 08/2011
9FlavonoidsIBA
04/2024 - 02/2012
9Plasminogen Activators (Plasminogen Activator)IBA
12/2023 - 12/2010
9Biomarkers (Surrogate Marker)IBA
01/2023 - 12/2010
8licochalcone AIBA
02/2024 - 01/2014
8p38 Mitogen-Activated Protein KinasesIBA
01/2024 - 05/2007
8MelatoninIBA
07/2023 - 11/2016
7AntioxidantsIBA
04/2024 - 10/2013
7CaspasesIBA
01/2024 - 12/2013
7Caspase 3 (Caspase-3)IBA
01/2024 - 02/2012
7mangostinIBA
12/2023 - 12/2013
7Peptide Hydrolases (Proteases)FDA Link
06/2023 - 08/2011
7Messenger RNA (mRNA)IBA
04/2022 - 04/2004
6Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
12/2023 - 12/2005
6norcantharidinIBA
12/2022 - 01/2012
6fisetinIBA
01/2019 - 02/2012
5CurcuminIBA
01/2024 - 05/2021
5Small Interfering RNA (siRNA)IBA
01/2023 - 10/2013
5SaponinsIBA
01/2023 - 01/2018
5Matrix Metalloproteinase 2 (Gelatinase A)IBA
01/2019 - 08/2012
4CollagenIBA
12/2023 - 01/2020
4Reactive Oxygen Species (Oxygen Radicals)IBA
11/2023 - 07/2017
4timosaponin AIIIIBA
12/2022 - 01/2019
4MicroRNAs (MicroRNA)IBA
04/2022 - 12/2015
4Sorafenib (BAY 43-9006)FDA Link
04/2022 - 12/2014
4Lipocalin-2IBA
06/2021 - 12/2012
4Matrix Metalloproteinase 9 (Gelatinase B)IBA
10/2017 - 01/2015
4PTX3 proteinIBA
01/2016 - 10/2011
4Protein Kinase C-alphaIBA
01/2015 - 02/2007
3asiatic acidIBA
04/2024 - 06/2022
3EnzymesIBA
04/2024 - 01/2008
3JNK Mitogen-Activated Protein KinasesIBA
01/2024 - 11/2016
3Cadherins (E-Cadherin)IBA
12/2023 - 09/2011
3VimentinIBA
12/2023 - 01/2020
3U 0126 (UO 126)IBA
12/2023 - 01/2019
3corosolic acidIBA
10/2023 - 08/2021
3(3,5- bis((4- fluorophenyl)methylidene)- 1- ((1- hydroxy- 2,2,5,5- tetramethyl- 2,5- dihydro- 1H- pyrrol- 3- yl)methyl)piperidin- 4- one)IBA
10/2023 - 01/2022
3protodioscinIBA
01/2023 - 01/2018
3Cytochromes c (Cytochrome c)IBA
12/2022 - 12/2013
3Cantharidin (Cantharides)IBA
12/2022 - 10/2017
3Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
09/2021 - 04/2018
3Anticarcinogenic AgentsIBA
05/2021 - 01/2017
3praeruptorin AIBA
04/2021 - 12/2017
3anomalinIBA
04/2020 - 01/2019
3Retinal Pigments (Pigments, Visual)IBA
01/2020 - 05/2018
3cathepsin SIBA
01/2020 - 10/2017
3Caspase 8 (Caspase-8)IBA
05/2016 - 02/2012
3Protein Kinases (Protein Kinase)IBA
01/2015 - 05/2007
3Chloride-Bicarbonate AntiportersIBA
07/2009 - 08/2006
2tricetinIBA
04/2024 - 01/2015
2TriterpenesIBA
04/2024 - 10/2023
2Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA
04/2024 - 06/2023
2HMGB1 Protein (HMG1)IBA
07/2023 - 04/2015
2Antineoplastic Agents (Antineoplastics)IBA
01/2022 - 05/2016
2CytokinesIBA
11/2021 - 06/2021
2ChemokinesIBA
11/2021 - 10/2018
2Paclitaxel (Taxol)FDA LinkGeneric
11/2021 - 01/2015
2Chemokine ReceptorsIBA
05/2021 - 09/2010
2FITC-annexin A5IBA
05/2021 - 09/2019
2IntegrinsIBA
03/2021 - 11/2020
2Carbonic Anhydrase IXIBA
03/2021 - 10/2017
2Transcription Factors (Transcription Factor)IBA
01/2021 - 12/2015
2Metalloproteases (Metalloproteinases)IBA
01/2020 - 01/2016
2Epidermal Growth Factor (EGF)IBA
01/2020 - 01/2015
2Apoptosis Regulatory ProteinsIBA
12/2019 - 07/2012
2Annexin A5IBA
11/2019 - 01/2018
2nimbolideIBA
09/2018 - 09/2015

Therapy/Procedure

10Therapeutics
12/2022 - 02/2007
7Drug Therapy (Chemotherapy)
07/2023 - 05/2016
3Chinese Traditional Medicine (Traditional Chinese Medicine)
07/2023 - 01/2017
3Chemoprevention
10/2015 - 01/2014